论文部分内容阅读
为了探讨明胶酶 (MMP- 2和 MMP- 9)在间叶肿瘤的浸润与转移中的意义 ,用免疫组化和酶谱分析的方法 ,对多种病理分类的 45例骨和软组织肿瘤中 ,MMP- 2和 MMP- 9的表达和活性进行了检测。结果发现骨和软组织来源的恶性肿瘤中 ,MMP- 2和 MMP- 9的阳性表达率和活性均高于良性肿瘤和正常组织。在恶性肿瘤中MMP- 2和 MMP- 9阳性的肿瘤细胞常呈不均匀的灶性分布 ,或在肿瘤巢边缘或浸润活跃处集中分布 ,可能与骨和软组织恶性肿瘤的侵袭性生物学行为有关
In order to explore the significance of gelatinases (MMP-2 and MMP-9) in infiltration and metastasis of mesenchymal tumor, using immunohistochemistry and zymogram analysis, 45 cases of bone and soft tissue tumors of various pathological classification, The expression and activity of MMP-2 and MMP-9 were examined. The results showed that the positive expression rates and activities of MMP-2 and MMP-9 in malignant tumors of bone and soft tissue were higher than those in benign tumors and normal tissues. In malignant tumors, MMP-2 and MMP-9-positive tumor cells often have a non-uniform distribution of lesions, or in the nested edge of the tumor or infiltration of active focus may be related to aggressive biological behavior of bone and soft tissue tumors