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目的:研究了高频交流电信号对神经动作电位的阻断作用。方法:采用离体的蟾蜍坐骨神经进行实验,对神经施加高频的正弦信号,观察动作电位的幅度和肌肉的状态来确定阻断的效果。结果:在一定频率下,高频正弦信号能完全阻断神经传导,阻断的阈值随阻断信号频率的增加而增加。给肌肉一小段时间高于阻断信号频率的刺激,肌肉对高频信号的强直效应会消失,之后肌肉的收缩也能被高频信号阻断。结论:高频电刺激对神经动作电位阻断作用为临床局麻、镇痛和解痉探索提供了新的依据。
Objective: To study the blocking effect of high frequency AC signal on nerve action potential. Methods: The isolated toad sciatic nerve was used to experiment. The high frequency sinusoidal signal was applied to the nerve to observe the magnitude of the action potential and the state of the muscle to determine the blocking effect. Results: Under a certain frequency, high-frequency sinusoidal signal completely blocked the nerve conduction, and the blocking threshold increased with the increase of the blocking signal frequency. Muscles for a short period of time higher than the frequency of the blocking signal stimulation, the muscles of the tonic effect of high-frequency signals will disappear, after the contraction of the muscles can be blocked by high-frequency signals. Conclusion: The blocking effect of high-frequency electrical stimulation on nerve action potential provides a new basis for the exploration of clinical anesthesia, analgesia and spasticity.