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以2,4-二氯苯甲酸为原料,经酯化、胺化、取代和环合4步反应合成了中间体3-巯基-4-氨基-5-(2,4-二氯)苯基-1,2,4-三唑(4)。以乙腈为溶剂,K2CO3为催化剂,4与2-(2-氯乙酰氨基)-3-甲基-N-丙基苯甲酰胺于室温反应3 h合成了2-[4-氨基-5-(2,4-二氯苯基)-4H-1,2,4-三唑-3-硫亚甲基酰胺]-3-甲基苯甲酰正丙胺,收率78%,其结构经1H NMR,IR,ESI-MS和元素分析确证。
The intermediate 3-mercapto-4-amino-5- (2,4-dichloro) phenyl was synthesized from 2,4-dichlorobenzoic acid by esterification, amination, -1,2,4-triazole (4). The title compound was synthesized by the reaction of 4 with 2- (2-chloroacetamido) -3-methyl-N-propylbenzamide with acetonitrile as solvent and K2CO3 as catalyst for 3 h at room temperature. 2,4-dichlorophenyl) -4H-1,2,4-triazole-3-thiamethyleneamide] -3-methylbenzoylpropylamine in 78% yield. Its structure was confirmed by 1H NMR IR, ESI-MS and elemental analysis.