目的肾上腺髓质素（Ａｄｒｅｎｏｍｅｄｕｌｉｎ，ＡＤＭ）是新近发现的对心血管系统具有重要作用的血管活性多肽，本研究旨在探讨特技飞行对血浆ＡＤＭ含量的影响及其意义。方法以１６名健康飞行人员为试验对象，另设１６名健康地勤人员为对照组。飞行人员进行复杂特技飞行，其最大加速度为＋６．５ＧＺ。飞行人员组于特技飞行前（６：００ａ．ｍ．空腹）、特技飞行后即刻（１０：００ａ．ｍ．）和特技飞行后６ｈ（４：００ｐ．ｍ．）取血，对照组于上述同步时间取血，用放免方法测定血浆ＡＤＭ含量。结果①特技飞行前，飞行人员组血浆ＡＤＭ含量明显高于对照组（Ｐ＜０．００１）。②飞行人员组血浆ＡＤＭ含量在特技飞行后即刻较飞行前明显降低（Ｐ＜０．００１），６ｈ后其血浆ＡＤＭ含量恢复到飞行前水平。③对照组血浆ＡＤＭ含量在特技飞行前、特技飞行后即刻和特技飞行后６ｈ的同步时间比较均无显著变化。结论飞行人员血浆ＡＤＭ基础含量较地勤人员高，可能与飞行人员经常承受飞行因素的影响有关。特技飞行可引起血浆ＡＤＭ含量明显降低，其主要原因可能与特技飞行时血流动力学变化有关，并对维持心脑血液供应具有重要意义 Objective Adrenomelin (ADM) is a recently discovered vasoactive peptide that plays an important role in the cardiovascular system. This study aimed to explore the effect and significance of aerobatic flight on the plasma ADM content. Methods Twenty-six healthy flight crew members were used as experimental subjects, and another 16 healthy ground crew members were included as control group. Flight crews perform complex aerobatics with a maximum acceleration of + 6.5GZ. The flight crew took blood before aerobatics (6:00 a.m. fasting), aerobatics immediately after aerobatics (10:00 a.m.) and aerobatics 6h (4:00 p.m.), and the control group received the above-mentioned synchronization Blood was taken from time to time, and plasma ADM level was measured by radioimmunoassay. Results ① The levels of ADM in flight crew before flight were significantly higher than those in control group (P <0.001). (2) Plasma ADM levels in flight crew decreased significantly immediately before flight (P <0.001), and plasma ADM level returned to pre-flight level after 6 h. ③ In the control group, there was no significant change in the plasma ADM content before aerobatics, aerobatics immediately and aerobatic 6h after aerobics. Conclusion The basic plasma ADM levels of pilots are higher than that of ground crew, which may be related to the frequent flight factors of pilots. Aerobatics can cause a significant decrease in plasma ADM levels, which may be related to hemodynamic changes during aerobatics and are important for maintaining cardiovascular and blood supply