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临床报导,苯乙双胍(Phenformin.P)有纤维蛋白溶解作用,但动物实验试不出来。鉴于患者在给药前的血浆纤溶活力已被抑制,因此在狗和大鼠的实验中也预先用胰岛素来抑制血浆纤溶活力。本文选择在常规试验中没有作用的 P 来检验这个模型。狗禁食过夜,皮下给胰岛素(2单位/公斤)前和4小时后收集血样,用3.8%枸橼酸钠抗凝。24小时后静脉注射戍巴比妥钠35毫克/公斤麻醉,再
It has been reported clinically that phenformin.P has a fibrinolytic activity but animal experiments can not be performed. In view of the inhibition of plasma fibrinolytic activity in patients before administration, insulin was also previously used in dogs and rats to inhibit plasma fibrinolytic activity. This paper chooses P, which has no effect in routine tests, to test this model. Dogs fasted overnight and blood samples were collected before and 4 hours after subcutaneous insulin (2 units / kg), anticoagulated with 3.8% sodium citrate. 24 hours after intravenous sodium pentobarbital 35 mg / kg anesthesia, and then