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本文分别观察了74名铂(Pt)、邻苯二甲酸酐(PA)和甲苯二异氰酸甲酯作业工人的健康状况。并以80名正常人为对照,进行了放射免疫吸附试验(RIST),测定血清中总IgE含量;和用放射变应原吸附试验(RAST),测定其抗原特异性IgE含量。对其中的哮喘者和非哮喘者进行结果比较,发现RIST在铂工人的症状者有增高的趋势。而RAST在各种作业的哮喘者,除已脱离TDI作业的哮喘者外,其滴度及阳性率均有显著的提高。本文结果说明RAST技术对确立职业性哮喘的病因诊断是十分有意义的。本试验可以证明机体对特殊抗原是否存在速发型变态反应,以及反应的程度,但不是特指哮喘反应。因此,本试验必须结合病史及其他实验室检查指标,综合判断,进行职业性哮喘的病因诊断。
In this paper, we observed the health status of 74 platinum (Pt), phthalic anhydride (PA) and toluene diisocyanate methyl workers respectively. Radioimmunoassay (RIST) was performed in 80 normal controls to measure the total IgE level in serum. The level of antigen-specific IgE was measured by radioimmunoassay (RAST). Comparison of the results of asthma and non-asthma among them showed that RIST tended to increase in platinum workers. The RAST asthma in a variety of jobs, except those who have been separated from the TDI operation asthma, the titer and positive rates were significantly increased. The results of this paper show that RAST technology is very meaningful to establish the etiological diagnosis of occupational asthma. This test can prove the existence of the body on the specific antigen rapid-onset allergic reaction, and the extent of the reaction, but not specifically refers to the asthma response. Therefore, this test must be combined with medical history and other laboratory tests, comprehensive judgment, the cause of occupational asthma diagnosis.