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目的:评价不同剂量氟康唑对难治性隐球菌脑膜炎患者的临床疗效。方法:选取2014年5月—2016年5月间医院收治的难治性隐球菌脑膜炎患者92例,将其随机分为对照组和治疗组,每组46例;对照组患者给予常规剂量氟康唑(400 mg)治疗,治疗组患者给予高剂量氟康唑(800 mg)治疗,比较两组患者治疗后症状复常时间和住院时间,以及治疗后的总有效率和不良反应的发生率。结果:治疗组患者治疗后脑膜炎症状复常时间和住院时间明显短于对照组(P<0.05),总有效率明显高于对照组(P<0.05);治疗组患者用药期间不良反应的发生率明显低于对照组(P<0.05)。结论:采用高剂量氟康唑治疗难治性隐球菌脑膜炎患者的临床疗效较佳,且脑膜炎症状复常时间和住院时间较短,且不良反应的发生率较低。
Objective: To evaluate the clinical efficacy of different doses of fluconazole in patients with refractory cryptococcal meningitis. Methods: Forty-two patients with refractory cryptococcal meningitis admitted to our hospital from May 2014 to May 2016 were randomly divided into control group and treatment group, with 46 patients in each group. Patients in the control group were given routine doses of fluoride (400 mg). The patients in the treatment group were treated with high-dose fluconazole (800 mg). The duration of symptom onset and hospital stay after treatment were compared between the two groups, and the total effective rate and incidence of adverse reactions after treatment . Results: After treatment, the time of recurrent and hospitalization of meningitis symptoms in treatment group was significantly shorter than that in control group (P <0.05), and the total effective rate was significantly higher than that in control group (P <0.05). The incidence of adverse reactions The rate was significantly lower than that of the control group (P <0.05). Conclusion: High-dose fluconazole in patients with refractory cryptococcal meningitis clinical efficacy is better, and the recurrent and hospitalized time meningitis symptoms shorter, and the incidence of adverse reactions is low.