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缝隙连接(GJ)通道是介导心肌细胞间电化学信息交流,保证心脏整体活动的协调性和同步性的特殊通道。在致心律失常发生上,GJ通道介导的细胞间电耦联障碍甚至比膜离子通道功能紊乱起了更重要的作用。连接蛋白43(Cx43)是心室GJ通道的主要构成成份,其表达和分布的异常将导致心室肌细胞的整体性异常,从而传导速度和传导各向异性发生改变,产生折返和传导阻滞。以GJ通道为作用靶点的新一代抗心律失常药的出现将为心律失常的治疗带来新的希望。
Gap junctions (GJ) channels are special channels that mediate the exchange of electrochemical information between cardiomyocytes and ensure the coordination and synchronization of cardiac activity as a whole. GJ channel-mediated intercellular coupling disorder is even more important than membrane ion channel dysfunction in the development of arrhythmias. Connexin 43 (Cx43) is a major component of the ventricular GJ pathway. Abnormalities in its expression and distribution lead to global abnormalities in ventricular myocytes, resulting in changes in conduction velocity and conduction anisotropy resulting in rebound and block. The emergence of a new generation of antiarrhythmic drugs targeting GJ channels will bring new hope for the treatment of arrhythmia.