目的测定五味子及其制剂安眠胶囊中五味子醇甲的含量。方法:采用高效液相色谱法。Inertsil ODS-3,C18色谱柱(250mm×4.5mm,ID),粒径5μm),以甲醇-水(65:35)为流动相,流速1ml·min-1,检测波长为251nm,柱温为25±1℃。结果:在测定浓度范围内线性较好,r为O.9999。精密度RSD为0.92%;重现性RSD为2.10%;回收率的平均值为101.12%,RSD=2.98%。结论:方法简便快速,可用于质量标准中含量测定。 Objective To determine the content of schisandrin A in schisandra and its preparation. Method: High performance liquid chromatography. Inertsil ODS-3, C18 column (250mm×4.5mm, ID), particle size 5μm) with methanol-water (65:35) as mobile phase, flow rate 1ml·min-1, detection wavelength at 251nm, column temperature 25±1°C. Results: Linearity was better within the measured concentration range, r was O.9999. The precision RSD was 0.92%; the reproducibility RSD was 2.10%; the average recovery rate was 101.12% and the RSD was 2.98%. Conclusion: The method is simple and rapid and can be used for content determination in quality standards.