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目的:观察二甲双胍联合吡格列酮对2型糖尿病患者血糖、高敏C反应蛋白的影响。方法:2型糖尿病患者60例随机分为2组。A组30例给予二甲双胍联合格列吡嗪治疗,B组30例给予二甲双胍联合吡格列酮治疗,疗程均为3个月。比较2组治疗前后空腹血糖、餐后2 h血糖、糖化血红蛋白、空腹胰岛素、胰岛素抵抗、高敏C反应蛋白水平。结果:2组治疗后空腹血糖、餐后2 h血糖、糖化血红蛋白均较治疗前下降(P<0.05);B组空腹胰岛素、胰岛素抵抗、高敏C反应蛋白水平较治疗前降低(P<0.05),且低于A组治疗后水平(P<0.01)。结论:二甲双胍联合吡格列酮可降低血糖,改善胰岛素抵抗。
Objective: To observe the effect of metformin combined with pioglitazone on blood glucose and high-sensitivity C-reactive protein in type 2 diabetic patients. Methods: Sixty patients with type 2 diabetes were randomly divided into two groups. 30 patients in group A were treated with metformin and glipizide, and 30 patients in group B were treated with metformin and pioglitazone. The course of treatment was 3 months. Fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, fasting insulin, insulin resistance, and high-sensitivity C-reactive protein levels were compared between the two groups before and after treatment. Results: The fasting blood glucose, postprandial 2-hour postprandial blood glucose and HbA1c in both groups were significantly lower than those before treatment (P <0.05). Fasting insulin, insulin resistance and high-sensitivity C-reactive protein in group B were lower than those before treatment , And lower than that of group A after treatment (P <0.01). Conclusion: Metformin combined with pioglitazone can reduce blood glucose and improve insulin resistance.