论文部分内容阅读
目的探讨血浆微量元素与非酒精性脂肪性肝病(NAFLD)的相关性。方法选取体检NAFLD患者30例(A组)及同期健康人群61例(B组),测定两组肝功能酶学指标及血浆微量元素水平,分析NAFLD发生的影响因素。结果 A组BMI和ALT、ALP和γ-谷氨酰转移酶(γ-GT)水平均高于B组,而血浆镍和锌水平低于B组(P<0.05)。以年龄、性别为控制变量行偏相关分析,结果显示,钴与ALT、铁与AST呈正相关,镍、铜与ALP呈负相关(P<0.05)。多因素Logistic回归分析显示,ALP和γ-GT水平升高是NAFLD发生的危险因素(P<0.01),而血浆锌水平的升高可能是NAFLD发生的保护因素(P<0.01)。结论血浆微量元素铁、钴、镍、铜和锌等可能和NAFLD的发生、发展相关,NAFLD患者应注重适当补充微量元素锌。
Objective To investigate the correlation between plasma trace elements and non-alcoholic fatty liver disease (NAFLD). Methods Thirty patients with NAFLD (group A) and 61 healthy subjects (group B) were enrolled in the study. Enzymatic index and plasma trace element levels were measured in two groups, and the influencing factors of NAFLD were analyzed. Results The levels of BMI, ALT, ALP and γ-GT in group A were higher than those in group B, while the plasma levels of nickel and zinc were lower than those in group B (P <0.05). Partial correlation analysis with age and sex as control variables showed that there was a positive correlation between cobalt and ALT, iron and AST, and negative correlation between nickel and copper with ALP (P <0.05). Multivariate Logistic regression analysis showed that elevated ALP and γ-GT were risk factors for NAFLD (P <0.01), while elevated plasma zinc level may be the protective factor of NAFLD (P <0.01). Conclusion Plasma trace elements such as iron, cobalt, nickel, copper and zinc may be related to the occurrence and development of NAFLD. NAFLD patients should pay attention to the appropriate supplementation of trace element zinc.