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目的探讨妊娠期肝内胆汁淤积症(ICP)合并乙型肝炎病毒感染的妊娠结局。方法回顾性总结2006年1月-2007年12月陕西省妇幼保健院86例ICP合并乙型肝炎病毒感染者(研究组),同期住院治疗的单纯ICP孕妇118例(对照组)的妊娠结局,比较两组的早产率、新生儿窒息率、产后出血率等并发症的发生情况。结果妊娠期肝内胆汁淤积症合并乙型肝炎病毒感染各并发症的发生情况:早产76例、妊娠期高血压疾病17例、产后出血8例。与对照组并发症的发生差异有显著性(P<0.05)。结论妊娠期肝内胆汁淤积症合并乙型肝炎病毒感染对母婴结局产生更严重的影响。加强母婴监护,药物治疗同时适时终止妊娠可有效改善妊娠结局。
Objective To investigate the pregnancy outcome of intrahepatic cholestasis of pregnancy (ICP) with hepatitis B virus infection. Methods The clinical data of 86 pregnant women with ICP and hepatitis B virus infection (study group) from January 2006 to December 2007 in Shaanxi MCH hospital were retrospectively reviewed. The pregnancy outcome of 118 pregnant women with simple ICP during hospitalization in the same period (control group) Premature birth rate, neonatal asphyxia, postpartum hemorrhage and other complications were compared between the two groups. Results The incidence of complications of intrahepatic cholestasis of pregnancy with hepatitis B virus infection was 76 cases of premature delivery, 17 cases of hypertensive disorder during pregnancy and 8 cases of postpartum hemorrhage. Comparing with the control group, the difference was significant (P <0.05). Conclusion Intrahepatic cholestasis of pregnancy with hepatitis B virus infection has a more serious impact on maternal and infant outcomes. Strengthening maternal and child custody, drug treatment while timely termination of pregnancy can effectively improve the pregnancy outcome.