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白血病细胞的增殖、分化、成熟及凋亡受体内免疫网络的调控,白血病的发生、发展与人体失控的免疫调控和骨髓造血微环境的异常改变有关。肝细胞生长因子(hepatocyte growthfactor,HGF)是人体免疫网络中的重要成员,HGF能单独刺激白血病来源的单个核细胞干细胞的增殖和克隆形成,增强白血病细胞与基质细胞的粘附并诱导白血病细胞的迁移,提示HGF 与白血病的发生、发展和预后关系密切,极可能发挥着重
Proliferation, differentiation, maturation and apoptosis of leukemia cells are regulated by the immune network in the body. The occurrence and development of leukemia are related to the uncontrolled immune regulation and the abnormal changes of bone marrow microenvironment. Hepatocyte growth factor (HGF) is an important member of human immune network. HGF can stimulate the proliferation and clone formation of leukemia-derived mononuclear stem cells separately, enhance the adhesion between leukemia cells and stromal cells and induce the leukemia cells Migration, suggesting that HGF and the occurrence of leukemia, development and prognosis are closely related, is likely to play a