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目的 探讨慢性肾功能衰竭血清Ⅳ型胶原的变化及意义。方法 采用放射名疫法对84例经临床上诊断为慢性肾功能衰竭患者及45例正常人血清Ⅳ型胶原水平进行检测。结果慢性肾功能衰竭氮质血症期患者血清Ⅳ型胶原水平与正常对照组相比无统计学意义;慢性肾功能衰竭期及尿毒症期血清Ⅳ型胶原水平明显高于正常对照组。结论血清Ⅳ型胶原水平可反映肾脏损害的程度,常规检测血清Ⅳ型胶原水平,可作为一项辅助、无创伤性检测慢性肾功能衰竭病情进展的较敏感的指标。
Objective To investigate the changes and significance of serum type Ⅳ collagen in patients with chronic renal failure. Methods The serum level of type Ⅳ collagen in 84 patients with clinically diagnosed chronic renal failure and 45 normal controls were detected by the method of radioimmunity. Results The level of serum type Ⅳ collagen in patients with chronic renal failure with azotemia was not significantly different from that in the control group. The levels of serum type Ⅳ collagen in patients with chronic renal failure and uremia were significantly higher than those in the normal control group. Conclusions The serum level of type Ⅳ collagen can reflect the extent of renal damage. The routine detection of serum level of type Ⅳ collagen can be used as a sensitive and noninvasive index for detecting the progression of chronic renal failure.