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用双色流式细胞术检测了被调查者外周血CD4~+T细胞中T细胞抗原受体(TCR)基因(α或β)表达缺陷的T细胞突变率(MF).调查对象为:原爆幸存者,氧化钍胶体(含放射性~228Th)使用者,用~(131)I治疗的甲状腺疾病患者,一名在切尔诺贝利核电站事故中严重受照者.以前的研究表明,未受过明显较大电离辐射照射的健康人员的外周血CD4~+T细胞中TCR表达缺陷的MF为2.5×10~(-4).在203名原爆幸存者中,78人受到近距离照射(DS86剂量≥1.5Gy),男女之MF分别为4.0×10~(-4)和2.7×10~(-4);125人受到远距离照射(DS86剂量<0.005Gy),男女之MF分别为0.33
The T cell mutation rate (MF) of T cell antigen receptor (TCR) gene (α or β) in CD4 ~ + T cells in peripheral blood of respondents was examined by two-color flow cytometry. , A patient suffering from thyroid disease treated with ~ (131) I, a serious incinerator at the Chernobyl nuclear accident, previously reported to have not been significantly affected by the use of thorium oxide colloid (containing ~ 228Th radioactivity) The MF of defective TCR expression in peripheral blood CD4 ~ + T cells from healthy volunteers exposed to large ionizing radiation was 2.5 × 10 ~ (-4). Of the 203 primary blast survivors, 78 were irradiated at close range (DS86 dose ≥ MF was 4.0 × 10 -4 and 2.7 × 10 -4 respectively; 125 subjects were exposed to long-range radiation (DS86 dose <0.005 Gy), and the MF of male and female were 0.33