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目的分析急性驰缓性麻痹(acute flaccid paralysis,AFP)病例、健康人群粪便标本病原学监测结果,为保持无脊灰状态提供实验室依据。方法病毒分离及鉴定,脊灰病毒株型内鉴别,确定疫苗株或野病毒株。结果青海省2008-2012年AFP病例、健康人群粪便标本782份,分离出脊髓灰质炎病毒2株,分离率为0.26%,其中脊灰I型疫苗株1株,脊灰混合型疫苗株1株,无脊灰野病毒株。分离到非脊灰肠道病毒(non-polio enterovirus,NPEV)162株,分离率为20.72%。结论我省2008-2012年无本地脊灰野毒株病例流行,阻断了脊灰本地野病毒的传播,保持了无脊灰状态。
Objective To analyze the etiological monitoring results of stool specimens from acute flaccid paralysis (AFP) cases and healthy people and provide laboratory evidence for maintaining polio-free status. Methods Isolation and identification of viruses, poliovirus type identification, to identify vaccine strains or wild virus strains. Results A total of 782 faecal samples were collected from Qinghai Province during 2008-2012 and healthy people. Two poliovirus strains were isolated from the healthy population. The isolation rate was 0.26%. One poliovirus type I vaccine strain, one poliovirus type vaccine strain, , Non-polio wild strain. 162 non-polio enterovirus (NPEV) isolates were isolated with the isolation rate of 20.72%. Conclusion No cases of wild poliovirus strains were found in our province from 2008 to 2012, which blocked the transmission of wild poliovirus and maintained polio-free status.