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目的 探讨军人心理创伤后应激障碍 ( PTSD)患者 3种事件相关电位 ( ERP)的变异。方法 应用美国 Nicolet Bravo脑诱发电位仪 ,采用光和声成对刺激、反应时间以及听觉靶 -非靶刺激序列技术 ,检测 66例 PTSD和 3 6名正常人 ( NC)的关联性负变 ( CNV)、P30 0 、以及失配性负波 ( MMN)。结果 1 CNV:M1 潜伏期 PTSD组 [( 5 0 3 .4± 1 3 9.2 ) ms]长于 NC组[( 4 2 0 .1± 1 2 3 .6) ms;P<0 .0 1 ],M2 波幅 PTSD组 [( 1 8.9± 7.9) μv]高于 NC组 [( 1 1 .7± 5 .8) μv;P<0 .0 1 ],指令信号后负变化 ( PINV)的出现率 PTSD组 ( 3 9% )高于 NC组 ( 3 % ;P<0 .0 1 )。 2 P30 0 :在靶刺激中 ,Cz脑区的 P3潜伏期 PTSD组[( 3 1 5 .4± 1 7.8) ms]短于 NC组 [( 3 3 6.7± 1 5 .5 ) ms;P<0 .0 1 ],Pz脑区的 N2 潜伏期 PTSD组 [( 2 78.5± 2 1 .8) ms]长于 NC组 [( 2 63 .4± 1 4.2 ) ms;P<0 .0 1 ],Pz脑区的 P3波幅 PTSD组 [( 3 .4± 1 .8) μv]低于 NC组 [( 5 .9± 2 .4) μv;P<0 .0 1 ]。在非靶刺激中 ,Cz脑区的 P2 波幅 PTSD组 [( 2 .5± 1 .4) μv]低于 NC组 [( 3 .4± 0 .1 ) μv;P<0 .0 1 ]。 3 MMN:潜伏期 PTSD组[( 2 1 4.2± 2 5 .7) ms]长于 NC组 [( 1 93 .7± 2 2 .6) ms;P<0 .0 1 ],波幅 PTSD组 [( 8.5
Objective To investigate the variation of three event related potentials (ERP) in military patients with posttraumatic stress disorder (PTSD). Methods Sixty-six patients with PTSD and 36 normal subjects (NC) were tested for the negative association (CNV) by using the Nicolet Bravo brain evoked potentiometer in the United States. Pairwise stimulation with light and sound, reaction time and auditory target- ), P30 0, and Mismatch Negative Wave (MMN). Results 1 CNV: The latency of [(5 0 3 .4 ± 1 3 9.2) ms] in the PTSD group was longer than that in the NC group [(421 ± 1223.6 ms; P <0 01), M2 The amplitude of PTSD group [(8.9 ± 7.9) μv] was higher than that of NC group [(11.7 ± 5.8) μv; P <0.01] (39%) were higher than those in NC group (3%; P <0.01). 2 P30 0: In the target stimulation, P3 latency in the Cz brain region was shorter than that in the NC group [(31.5.4 ± 7.85 ms vs P34 (P <0.001), while Pz brain length in Pz brain area was significantly longer than that in NC group [(2 63.4 ± 1.22) ms; P <0.01] The amplitude of P3 amplitude in PTSD group [(3.4 ± 1.8) μv] was lower than that in NC group [(5.9 ± 2.4) μv; P <0.01). In non-target stimulation, P2 amplitude in Cz brain region was lower than that in NC group [(3.4 ± 0.11) μv; P <0.01] in PTSD group [(2.5 ± 1.4) μv]. 3 MMN: The latency of the PTSD group [(2 1 4.2 ± 2.57) ms] was longer than that of the NC group [(1 93.7 ± 2.2 2.6) ms; P <0.01]