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阴虚、阳虚是中医临床常见证候,对其发病机理、辨证分型、物质基础的研究有助于对疾病的诊断、治疗及预后。动物状态模型的研究及应用是相关研究的重要环节,在对传统中医阴虚、阳虚状态概念界定和现代实质表达进行回顾的基础上,结合中医药对糖皮质激素副作用的认识理解,分析归纳糖皮质激素诱导阴虚、阳虚状态动物模型实验研究现状和病理特征,进而引发从病因—病理、症状—客观指标、方药治疗—反证的角度,对糖皮质激素诱导阴虚、阳虚状态模型进行诊断和评价的思考,以期为此类状态模型的规范研究和推广应用提供参考。
Yin, yang deficiency is a common clinical syndrome in TCM, its pathogenesis, syndrome differentiation, material basis of research contribute to the diagnosis, treatment and prognosis of the disease. The research and application of animal state model is an important part of related research. On the basis of reviewing the definition of traditional Chinese medicine yin deficiency and yang deficiency state and modern substantive expression, combined with understanding of the side effects of traditional Chinese medicine on glucocorticoid, Glucocorticoid induces the experimental research status and pathological features of animal models of yin deficiency and yang deficiency, and then triggers the study of glucocorticoid-induced yin deficiency and yang deficiency from the perspective of etiology-pathology, symptom-objective indicators and prescription treatment- Diagnosis and evaluation of thinking, in order to provide a reference for the research and popularization and application of such state model.