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氯吡格雷抵抗是冠心病复发性血栓事件的最主要原因之一,发生机制与患者疾病状态、CYP2C19等基因多态性及合并用药存在相互作用等有关。临床药师通过参与冠心病患者的药物治疗,排查氯吡格雷抵抗患者,结合基因检测结果、疾病状态、药物相互作用等,协助医生优化抗血小板治疗方案,开展个体化药学监护,并建立氯吡格雷抵抗冠心病患者的药学服务路径。
Clopidogrel resistance is one of the most important causes of recurrent thrombotic events in coronary heart disease. The mechanism of occurrence of clopidogrel is related to disease status of patients, genetic polymorphism of CYP2C19 and the interaction of drug combination. Clinical pharmacists through the participation of patients with coronary heart disease drug treatment, investigation of patients with clopidogrel resistance, combined with genetic test results, disease status, drug interactions, to help doctors optimize anti-platelet therapy programs, to carry out individualized pharmacy monitoring, and the establishment of clopidogrel Resistance to coronary heart disease in patients with pharmacy service path.