采用非损伤性荧光标记技术评价马来酸噻吗洛尔眼用凝胶制剂的眼部消除动力学。2009年3月,我们以马来酸噻吗洛尔眼用缓释凝胶制剂为受试制剂[1],市售马来酸噻吗洛尔滴眼液为参比制剂,研究受试制剂在兔眼内的药代动为学。1试剂材料大耳白家兔,雌雄兼用,体重2.5~3.0kg,由北京维通 Non-invasive fluorescent labeling was used to evaluate ocular elimination kinetics of timolol maleate gel formulations. In March 2009, we took timolol maleate sustained release gel preparation as the test preparation [1], timolol maleate eye drops as the reference preparation, the study preparation Pharmacokinetics in the rabbit eye as a science. 1 Reagents Large white rabbits, both male and female, body weight 2.5 ~ 3.0kg, by Beijing Vital