论文部分内容阅读
目的探讨选择性单胚胎移植的妊娠结局及可行性。方法回顾性分析我院生殖中心2007年1月-2010年10月实施的所有体外受精-胚胎移植(IVF-ET)新鲜周期中行D3 d单胚胎移植的125个周期,其中选择性单胚胎移植39个周期(A组),仅有单个胚胎可移植的86个周期(B组),分析和比较两组单胚胎移植的年龄、不孕时间、基础FSH值、获卵数、胚胎卵裂球数及优胚数、HCG日内膜厚度及E2值、临床妊娠率及流产率的差异。结果 A、B两组的年龄、不孕时间、基础FSH值、获卵数、移植胚胎卵裂球数及优胚数、HCG日内膜厚度及E2值、临床妊娠率及流产率分别为(28.89±3.223)岁和(34.01±4.809)岁;(4.31±2.776)年和(6.30±5.332)年;(5.5±2.256)IU/L和(10.26±3.757)IU/L;(5.42±2.649)个和(1.75±0.324)个;(10.58±3.46)个和(5.39±2.45)个;(1.42±0.649)个和(1.75±0.724)个;(1.25±2.965)mm和(10.02±1.962)mm;(10 132±4 303)pmmol/L和(5 982±2 108)pmmol/L;46.15%(18/39)和27.91%(24/86);22.22%和37.5%。A组的平均年龄、不孕时间、基础FSH值、获卵数明显小于B组,其差异有统计学意义(P<0.05)。A组的HCG日E2值和临床妊娠率明显高于B组,其差异有统计学意义(P<0.05)。A、B两组移植胚胎的卵裂球数目、HCG日内膜厚度、流产率差异无统计学意义(P>0.05),但A组的流产率(22.22%)低于B组(37.50%)。结论对于年龄小于35岁,卵巢储备功能正常者,选择D3 d优质单胚胎移植可达到较高的临床妊娠率而降低多胎率。
Objective To investigate the outcome of pregnancy with selective single embryo transfer and its feasibility. Methods Retrospective analysis of 125 cycles of D3 d single embryo transfer in fresh cycles of IVF-ET from January 2007 to October 2010 in our hospital was performed retrospectively. Selective single embryo transfer (Group A), only a single embryo was transplanted for 86 cycles (group B). The age, duration of infertility, basal FSH value, number of oocytes retrieved, number of embryo blastomeres And excellent embryo number, HCG endometrial thickness and E2 value, clinical pregnancy rate and abortion rate differences. Results The age, duration of infertility, basal FSH value, number of oocytes retrieved, number of blastomere and embryo transfer, HCG endomembrane thickness and E2 value, clinical pregnancy rate and abortion rate in groups A and B were ( (5.5 ± 2.256) IU / L and (10.26 ± 3.757) IU / L; (5.42 ± 2.649) years old and (34.01 ± 4.809) years old, (4.31 ± 2.776) years and (6.30 ± 5.332) And (1.75 ± 0.324), (10.58 ± 3.46) and (5.39 ± 2.45), (1.42 ± 0.649) and (1.75 ± 0.724), (1.25 ± 2.965) mm and (10.02 ± 1.962) mm ; (10 132 ± 4 303) pmmol / L and (5 982 ± 2 108) pmmol / L; 46.15% (18/39) and 27.91% (24/86); 22.22% and 37.5% respectively. The mean age, infertility time, basic FSH value and the number of oocytes retrieved in group A were significantly lower than those in group B (P <0.05). The E2 value and clinical pregnancy rate of HCG group in group A were significantly higher than those in group B, with a significant difference (P <0.05). There was no significant difference in the number of blastomeres, HCG intima-media thickness and abortion rate between the groups A and B (P> 0.05), but the abortion rate in group A (22.22%) was lower than that in group B (37.50% . Conclusion For those aged less than 35 years old and with normal ovarian reserve, high quality single embryo transfer with D3 d can achieve high clinical pregnancy rate and reduce multiple pregnancy rate.