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应用银染色技术检测３０例宫颈正常鳞状上皮、９０例宫颈不典型增生和１２０例宫颈鳞癌中细胞核内核仁组成区嗜银相关蛋白（ＡｇＮＯＲｓ，）颗粒的平均数目和每个ＡｇＮｏＲｓ颗粒的平均最大直径．结果：不典型增生和鳞癌细胞中ＡｇＮＯＲｓ颗粒的平均数目和最大直径均超过正常上皮，差异有显著性（Ｐ＜００１）；各级不典型增生和原位癌两两比较，ＡｇＮｏＲｓ颗粒数目和最大直径无显著差异（Ｐ＞００５）；原位癌，高、中、低分化癌两两比较，ＡｇＮＯＲｓ颗粒数目无显著性差异（Ｐ＞０．０５）但其最大直径逐级增加．表明：每核ＡｇＮＯＲｓ的颗粒数目对于宫颈鳞状上皮不典型增生和鳞癌的分级无诊断价值，但每个ＡｇＮＯＲＳ颗粒的平均最大直径却可作为宫颈鳞癌分级的辅助指标．
Silver staining was used to detect the average number of AgNORs in the nucleus of the nucleus and the average number of AgNORs in 90 cases of cervical squamous epithelium, 90 cases of cervical dysplasia, and 120 cases of cervical squamous cell carcinoma. The maximum diameter. RESULTS: The average number and maximum diameter of AgNORs in atypical hyperplasia and squamous cell carcinoma cells were higher than those in normal epithelium (P < 001). The number of AgNoRs particles in both atypical hyperplasia and carcinoma in situ was compared. There was no significant difference in maximal diameter (P>005). There was no significant difference in the number of AgNORs particles (P>0.05) in in situ carcinomas, with high, medium, and low differentiated carcinomas, but their maximum diameters increased gradually. The results showed that the number of AgNORs per core had no value in the diagnosis of squamous epithelial dysplasia and squamous cell carcinoma of the cervix, but the average maximum diameter of each AgNORS particle could be used as an auxiliary index for grading of cervical squamous cell carcinoma.