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胸苷激酶1(TK1)是一种重要的DNA合成关键酶,与细胞增殖分裂密切相关,是一种肿瘤增殖的标志物.TK1升高与早期恶性肿瘤的发生及肿瘤转移、复发相关,并且TK1在治疗中的变化也能够反映肿瘤对治疗的敏感性.循环肿瘤细胞(CTC)是从肿瘤原发灶或转移灶脱落入血的肿瘤细胞.恶性肿瘤中CTC的出现通常与转移复发、生存期缩短等不良预后有关,TK1与CTC联合还可以作为生存的一项独立预测因子.现对TK1及CTC在肿瘤发生发展过程中的作用进行分析及总结,作一综述.“,”Thymidine kinase 1 (TK1) is associated with the occurrence of early malignant tumor,tumor metastasis,recurrence,and the changes of TK1 in the treatment can also reflect the sensitivity of tumor to treatment.Circulating tumor cells (CTC) are removed from the primary tumor or metastatic tumor to blood.The appearance of CTC in malignant tumors is usually related to the poor prognosis,such as metastasis and recurrence,short survival time and so on.The combination of TK1 and CTC can also be used as an independent predictor of survival.Now we analyse and summarize the role of TK1 and CTC in tumorigenesis and development.