论文部分内容阅读
目的探讨苏州市汉族女性5,10-亚甲基四氢叶酸还原酶(MTHFR)和甲硫氨酸合成酶还原酶(MTRR)基因多态性的频率特征。方法以苏州市644例汉族女性为研究对象,检测MTHFR C677T、A1298C和MTRR A66G的基因分型。统计分析基因多态性的频率特征,并与已报道的其他地区汉族女性的数据进行比较。结果苏州市汉族女性的MTHFR C677T基因型和等位基因频率与淄博、郑州、松滋、昆明、德阳、惠州、琼海差异有统计学意义(P<0.05),MTHFR A1298C基因型和等位基因频率与淄博、松滋、德阳、惠州、琼海差异有统计学意义(P<0.05),MTRR A66G基因型和等位基因频率与琼海差异有统计学意义(P<0.05)。结论苏州市汉族女性MTHFR和MTRR基因多态性频率不同于其他地区,具有地域特异性。
Objective To investigate the frequency characteristics of 5,10-methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphism in Han women in Suzhou. Methods The genotypes of MTHFR C677T, A1298C and MTRR A66G were detected in 644 Han women in Suzhou City. The frequency characteristics of the genetic polymorphisms were statistically analyzed and compared with the reported data of Han women in other areas. Results The frequencies of MTHFR C677T genotypes and alleles in Suzhou Han women were significantly different from those in Zibo, Zhengzhou, Songzi, Kunming, Deyang, Huizhou and Qionghai (P <0.05), and the MTHFR A1298C genotypes and alleles There was significant difference between frequency and Zibo, Songzi, Deyang, Huizhou and Qionghai (P <0.05). There was significant difference between MTRR A66G genotype and allele and Qionghai (P <0.05). Conclusion The frequencies of MTHFR and MTRR gene polymorphisms in Han women in Suzhou are different from those in other regions and have the geographical specificity.