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细胞外钙受体也称为钙敏感受体(extracellular calcium sensing receptor,CaR),对调节机体细胞外钙的平衡发挥着重要作用。该受体不仅分布在甲状旁腺、骨、肾、肠这些与钙转移和钙稳态调节有关的器官,还广泛分布于许多其他与钙的稳定无关的组织细胞中,并通过PLC,PIK和MAPK等细胞内信号转导途经起着除钙稳态调节以外重要的细胞内作用,如保护细胞抗凋亡、细胞增殖等生物学作用,在心血管系统中,CaR也有重要的生理病理作用,本文综述了近些年关于CaR的结构、功能和信号转导及它在心血管系统中的作用。
Extracellular calcium receptors, also known as extracellular calcium sensing receptors (CaRs), play an important role in regulating the balance of extracellular calcium in the body. The receptor is distributed not only in organs such as parathyroid gland, bone, kidney and intestine, which are involved in calcium transfer and calcium homeostasis, but also widely distributed in many other tissue cells that are unrelated to calcium stability and are expressed by PLC, PIK and MAPK and other intracellular signal transduction pathways play an important role in the regulation of calcium in addition to the important intracellular role, such as protection of cells against apoptosis, cell proliferation and other biological role in the cardiovascular system, CaR also has important physiological and pathological effects, this article This review summarizes the recent studies on the structure, function and signal transduction of CaR and its role in the cardiovascular system.