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例1,女,70岁。因两下肢Kaposi肉瘤而注射博莱霉素,每周二次,每次15mg,病情显著好转,当总量达到240mg时患者出现雷诺氏现象,毛细血管镜检查,有类似硬皮病改变,抗着丝粒抗体阳性,其他内脏、代谢及免疫学检查均阴性。停药4个月后,雷诺氏现象明显改善,毛细管镜复查,仅见毛细血管密度较低,部分血管中度扩张伴郁滞,抗着丝粒抗体仍为阳性。停药6个月后,血管肉瘤恶化,重新注射博莱霉索后又很快出现明显的雷诺氏现象。例2,女,59岁。1976年因乳房腺癌施行手术、局部放疗及预防性化疗,应用博莱霉素(量不详),5-氟脲嘧啶等药物。在一年的化疗的过程中,患者逐渐出现雷诺氏现象,但进展缓慢,直到1984年才因此就诊。内脏检查无异常,抗着丝粒抗体阳性,免疫学检查正常,毛细血管镜检查为血管炎改变,例3,女性,71岁。患者因患免疫母细胞
Example 1, female, 70 years old. Bleomycin was injected twice daily for Kaposi’s sarcoma twice a week for 15 mg each and the condition was significantly improved. The patient developed Raynaud’s phenomenon when the total volume reached 240 mg. Capillary scanning revealed similar changes in scleroderma, Fibronectin positive, other visceral, metabolic and immunological tests were negative. After 4 months of withdrawal, Raynaud’s phenomenon was significantly improved. Reexamination by capillary tube showed that the capillary density was low, some of the blood vessels were moderately dilated with stagnation, and anti-centromere antibodies were still positive. Six months after withdrawal, angiosarcoma was deteriorated, and Raynaud’s phenomenon appeared soon after re-injection. Example 2, female, 59 years old. In 1976 due to breast cancer surgery, local radiotherapy and preventive chemotherapy, the application of bleomycin (an unknown amount), 5-fluorouracil and other drugs. In the course of one year of chemotherapy, Raynaud’s phenomenon gradually appeared in patients, but the progress was slow until 1984. Visceral examination was normal, anti-centromere antibody positive, immunological examination was normal, capillary angiography was vasculitic changes, Example 3, female, 71 years old. Patients suffering from immune cells