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目的:评价在高频振荡通气的基础上加用西地那非治疗新生儿持续肺动脉高压的临床疗效及安全性。方法:回顾性分析我院NICU自2011年1月~2013年1月应用西地那非联合高频振荡通气治疗的20例PPHN患儿的临床资料,所有患儿均监测治疗前后肺动脉压力(SPAP)、体循环血压(SBP)、血氧饱和度(SPO2)、氧分压(PO2)、pH值。结果:在高频振荡通气的基础上加用西地那非治疗后,患儿肺动脉压力、血氧饱和度、氧分压、pH值较用药前均明显改善,而SBP无明显下降。结论:西地那非联合高频振荡通气治疗新生儿持续性肺动脉高压安全有效。
PURPOSE: To evaluate the clinical efficacy and safety of sildenafil in the treatment of persistent pulmonary hypertension in neonates based on high-frequency oscillatory ventilation. Methods: The clinical data of 20 patients with PPHN treated with sildenafil combined with high-frequency oscillatory ventilation from NICU in our hospital from January 2011 to January 2013 were retrospectively analyzed. All patients were monitored for pulmonary arterial pressure (SPAP ), SBP, SPO2, PO2 and pH. Results: After treatment with sildenafil on the basis of high frequency oscillatory ventilation, pulmonary arterial pressure, oxygen saturation, oxygen partial pressure and pH in children were significantly improved compared with those before treatment, while SBP did not decrease significantly. Conclusions: Sildenafil combined with high-frequency oscillatory ventilation is safe and effective in the treatment of persistent pulmonary hypertension in neonates.