论文部分内容阅读
本文观察了丙线照射大鼠胃粘膜的易损性及其与由源性PG_s和血检素A_2的关系。结果表明:丙线1500rad局部照射后28天,大鼠对牛磺胆酸所致胃粘膜坏死易损性明显加重,预先给予外源性PGE_2则可抑制这一现象;进一步采用放射免疫方法测定胃粘膜PG_s等的含量发现,照射后组织PGE和PGI_2含量明显降低,而血栓素A_2含量则明显升高,PGI_2/血栓素A_2,比值下降。这些结果说明,丙线照射可使大鼠胃粘膜的易损性明显加重,而内源性PGE和PGI_2含量的降低以及血栓素A_2含量的升高是照射造成易损性的主要原因之一。
This article observed the vulnerability of gastric mucosa of rats irradiated with C-ray and its relationship with PG_s and blood A2. The results showed that after 28 days of local irradiation with C rays at 1500 rad, the rat’s gastric mucous membrane necrosis vulnerability was significantly aggravated by taurocholic acid. Exogenous PGE 2 pretreatment could inhibit this phenomenon, and radioimmunoassay was used to determine the stomach. The content of mucosal PG_s, etc. found that after irradiation, the content of PGE and PGI_2 decreased significantly, while the content of thromboxane A_2 increased significantly, and the ratio of PGI_2/thromboxane A_2 decreased. These results indicate that C-ray irradiation can significantly increase the vulnerability of gastric mucosa in rats, and the decrease of endogenous PGE and PGI 2 content and the increase of thromboxane A 2 content are one of the major causes of vulnerability caused by irradiation.