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目的回顾性分析2007～2011年柳州市新生儿先天性甲状腺功能减低症筛查与临床确诊关系,提高新生儿疾病筛查的有效性。方法新生儿出生72 h后采集足跟血滴于专用滤纸片上,采用时间分辨荧光免疫分析法检测滤纸片促甲状腺激素(TSH)浓度,筛查阳性者需召回取静脉血采用化学发光法检测甲状腺功能。结果柳州市新生儿疾病筛查中心2007～2011年共筛查新生儿198 913例,先天性甲状腺功能减低症筛查阳性1374例,阳性率0.7%,召回1208例,确诊原发性甲低126例,高TSH血症121例,筛查结果与确诊成正比关系,筛查的确诊符合率为20.4%。结论加强实验室筛查准确性和阳性召回工作,可保障先天性甲状腺功能减低症患儿的检出与治疗。
Objective To retrospectively analyze the relationship between congenital hypothyroidism (Hypothyroidism) and clinical diagnosis in newborns from 2007 to 2011 in order to improve the effectiveness of neonatal screening. Methods The heel blood was collected on a special filter paper 72 hours after birth. The TSH concentration in the filter paper was determined by time-resolved fluorescence immunoassay. Venous blood was collected from patients who were positive for screening. Chemiluminescence was used to detect thyroid Features. Results A total of 198 913 newborns were screened from 2007 to 2011 in Liuzhou Neonatal Disease Screening Center. 1374 cases of congenital hypothyroidism were screened positive, with a positive rate of 0.7%. 1208 cases were recalled and the diagnosis of primary hypothyroidism 126 Cases, 121 cases of high TSH hyperlipidemia, screening results and diagnosis is proportional to the screening confirmed the coincidence rate was 20.4%. Conclusion To strengthen the accuracy of laboratory screening and positive recall, to protect children with congenital hypothyroidism detection and treatment.