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采用热板法测定小鼠痛阈,发现ip褪黑素(MT)40mg·kg-1·d-1连续6d,镇痛作用持续、明显;ip哌替啶40mg·kg-1·d-1连续6d,镇痛作用逐渐减弱,至d6时已无镇痛作用。d7ipMT和哌替啶同上剂量1h时测定小鼠ConA诱导的脾淋巴细胞增殖反应,发现MT能明显提高淋巴细胞增殖反应,而哌替啶对小鼠脾淋巴细胞增殖反应有抑制趋向。结果提示:MT不同于哌替啶无耐受性,且能促进脾淋巴细胞功能。
The hot plate method was used to determine the pain threshold in mice. It was found that the melatonin (MT) 40 mg · kg-1 · d-1 was continuous for 6 days, Continuous 6d, analgesic effect gradually weakened, to d6 no analgesic effect. d7ipMT and pethidine at the same dose 1h measured ConA-induced lymphocyte proliferation in mice and found that MT can significantly increase the lymphocyte proliferation response, and pethidine on mouse spleen lymphocyte proliferation was inhibited. The results suggest that: MT is different from pethidine intolerance and can promote splenic lymphocyte function.