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目的:探讨影响卵巢浆液性腺癌复发与5年生存率的相关因素。方法:回顾分析1997年1月～2006年12月在复旦大学附属妇产科医院住院治疗的卵巢浆液性腺癌患者345例的临床资料,比较年龄、不同FIGO亚期、病理分级、手术范围、手术后有无残余病灶,盆腔淋巴结转移及不同化疗方案对复发及5年生存率的影响。结果:10年收治卵巢浆液性腺癌患者共345例,占同期收治的卵巢癌患者23.9%(1444例),5年生存率65.56%。单因素生存分析显示,FIGO临床分期对预后的影响最大,继而依次为有无残余病灶、年龄、化疗及病理分级。多因素分析显示,化疗和病理分级是影响5年生存率的独立因素。结论:卵巢浆液性腺癌患者手术后,化疗及病理分级是影响5年生存率的独立因素。年龄、FIGO亚期、有无淋巴结转移、有无残余病灶是影响其预后的相关因素。术前术中准确分期并施以适当的手术治疗,术后辅以化疗,对预后和提高5年生存率具有重要意义。
Objective: To investigate the related factors affecting the recurrence of ovarian serous adenocarcinoma and 5-year survival rate. Methods: The clinical data of 345 patients with ovarian serous adenocarcinoma hospitalized from January 1997 to December 2006 in Obstetrics and Gynecology Hospital of Fudan University were retrospectively analyzed. The age, different FIGO stages, pathological grade, surgical range, operation After residual tumor, pelvic lymph node metastasis and different chemotherapy regimens and 5-year survival rate. Results: A total of 345 cases of ovarian serous adenocarcinoma were treated in 10 years, accounting for 23.9% (1444 cases) of ovarian cancer patients treated in the same period. The 5-year survival rate was 65.56%. Univariate survival analysis showed that FIGO clinical stage had the greatest impact on prognosis, followed by residual tumor, age, chemotherapy and pathological grade. Multivariate analysis showed that chemotherapy and pathological grade were independent factors affecting 5-year survival rate. Conclusion: Chemotherapy and pathological grading after ovarian serous adenocarcinoma are independent factors affecting the 5-year survival rate. Age, FIGO sub-phase, with or without lymph node metastasis, with or without residual lesions are related factors that affect the prognosis. Preoperative accurate intraoperative and staging and appropriate surgical treatment, postoperative adjuvant chemotherapy, prognosis and improve the 5-year survival rate of great significance.