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目的研究分析硫酸氢氯吡格雷治疗不稳定型心绞痛的临床效果。方法 78例不稳定型心绞痛患者按照入院时间先后分为对照组和观察组,各39例。对照组采用常规方法 ,观察组在对照组基础上使用硫酸氢氯吡格雷治疗。对比两组患者临床治疗效果。结果观察组患者治疗总有效率为87.2%,明显高于对照组的66.7%,差异具有统计学意义(P<0.05)。治疗后,观察组患者生活质量评分为(8.2±1.9)分,明显高于对照组的(5.9±1.3)分,差异具有统计学意义(P<0.05)。治疗期间,观察组患者发生窦性心动过缓1例、头晕2例、乏力2例,不良反应发生率为12.8%;对照组患者发生窦性心动过缓2例、头晕2例、乏力2例,不良反应发生率为15.4%;两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论临床常规治疗方法与硫酸氢氯吡格雷在治疗不稳定型心绞痛方面均具有一定效果,但相对而言硫酸氢氯吡格雷效果更为明显,更有助于改善患者临床症状,提高患者生活质量,具有推广应用价值。
Objective To study the clinical effect of clopidogrel hydrogen sulfate in the treatment of unstable angina pectoris. Methods Seventy-eight patients with unstable angina pectoris were divided into control group and observation group according to the admission time, 39 cases in each. The control group using conventional methods, the observation group in the control group based on the use of clopidogrel hydrogen sulfate treatment. The clinical effects of two groups were compared. Results The total effective rate of observation group was 87.2%, significantly higher than that of control group (66.7%), the difference was statistically significant (P <0.05). After treatment, the quality of life in the observation group was (8.2 ± 1.9) points, which was significantly higher than that in the control group (5.9 ± 1.3), the difference was statistically significant (P <0.05). During the treatment period, one case of sinus bradycardia, two cases of dizziness, two cases of dizziness and 12.8% of adverse reactions occurred in the observation group. Two cases of sinus bradycardia, two cases of dizziness and two cases of weakness occurred in the control group , The incidence of adverse reactions was 15.4%. There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusions The clinical routine treatment and clopidogrel hydrogen sulfate have some effects in the treatment of unstable angina pectoris. However, the effect of clopidogrel hydrogen sulfate is more obvious, which is more helpful to improve the clinical symptoms and improve the quality of life of patients , With the promotion and application value.