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氧哌羟苯唑头孢菌素(Cefoperazone,缩写CPZ)为一第三代头孢菌素,1981年在我国试制成功。本品对各种革蓝氏阳性球菌包括产生β-内酰胺酶和不产β-内酰胺酶的金葡菌和肠道革蓝氏阴性杆菌和绿脓杆菌等具有显著的抗菌作用;本品还具有体内分布良好和毒性低的特点。本文报道国产氧哌羟苯唑头孢菌素正常人体内药代动力学研究结果和给药方案的探讨。
Cefoperazone (abbreviated CPZ) is a third-generation cephalosporin, which was successfully tested in China in 1981. The product of a variety of gram-positive cocci, including the production of β-lactamase and β-lactamase-producing Staphylococcus aureus and intestinal Gram-negative bacteria and Pseudomonas aeruginosa has a significant antibacterial effect; this product It also has good in vivo distribution and low toxicity. This article reports the domestic oxpaczin cephalosporin normal human pharmacokinetic study results and dosing regimen.