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目的 :研究疏肝健脾冲剂免疫增强的药理作用。方法 :应用环磷酰胺造成小白鼠免疫功能低下模型 ,通过小鼠游泳实验、常压缺氧实验 ,观察试验药物对机体免疫功能及抗应激能力的影响。结果 :疏肝健脾冲剂显著提高血清溶菌酶含量、半数溶血值、足垫肿胀厚度 (P <0 .0 5 ,<0 .0 1) ,显著延长小鼠常压缺氧死亡时间和游泳时间 (均P <0 .0 1)。结论 :疏肝健脾冲剂具有提高机体免疫功能和抗应激能力的作用 ,为其治疗脾胃病的作用机制之一。
Objective : To study the pharmacological effects of Shugan Jianpi Granule on immune enhancement. Methods :Cyclophosphamide was used to model the immune function of mice. The effects of the test drugs on immune function and anti-stress ability of mice were observed by mouse swimming experiment and atmospheric hypoxia test. Results: Shugan Jianpi Granules significantly increased serum lysozyme content, half hemolysis value, footpad swelling thickness (P < 0.05, <0.01), and significantly prolonged death time and swimming time of normoxic hypoxia in mice. (all P <0. 0 1). Conclusion: Shuganjianpi granules have the function of improving immune function and anti-stress ability, and are one of the mechanisms for treating spleen-stomach diseases.