目的探讨发作性睡病的临床表现、辅助检查、诊断、治疗及预后。方法对23例明确诊断的发作性睡病患者进行多导睡眠脑电图分析,采用苯丙胺、哌醋甲酯、丙咪嗪、阿米替林治疗,并进行随访3年。结果 23例患者均有日间不能克制的短暂睡眠发作,睡眠潜伏期缩短。结论发作性睡病是慢性神经系统疾病,结合其临床表现及睡眠脑电图可以早期诊断,尽早给予患者规范药物治疗、心理疏导,以提高患者的生活质量。 Objective To investigate the clinical manifestation, diagnosis, treatment and prognosis of narcolepsy. Methods Twenty-three patients with diagnosed narcolepsy were subjected to polysomnography (EEG) and were treated with amphetamine, methylphenidate, imipramine and amitriptyline and were followed up for 3 years. Results All the 23 patients had a transient sleep episode that could not be restrained during the day, and the sleep latency was shortened. Conclusion Narcolepsy is a chronic neurological disease. Combined with its clinical manifestations and sleep EEG, it can be diagnosed early, and patients can be treated with medication and psychological counseling as soon as possible so as to improve their quality of life.