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磷脂为构成胎盘绒毛膜的必需成分,已证实流产妇女妊娠期滋养层的抗原性刺激可导致抗体产生多种自身抗体如抗磷脂抗体等。抗磷脂机体可阻碍前列腺环素(prostacycline)的产生,并导致胎盘血管内血小板聚集,血管收缩增强,血栓形成及胎盘栓塞。最近发现一些复发性自发性流产(RSAs)患者及自身免疫病患者体内存在有抗心脂抗体及其它一些抗体,它们对磷脂有负调控作用。但这些抗体与RSAs间的关系尚不明了。
Phospholipid constitutes an essential component of the placental chorion, it has been confirmed that the antigenic stimulation of abortion trophoblast pregnancy women can lead to antibodies produce a variety of autoantibodies such as anti-phospholipid antibodies. Antiphospholipid antibodies can hinder the production of prostacycline and lead to placental platelet aggregation, enhanced vasoconstriction, thrombosis and placental embolism. Recently, some patients with recurrent spontaneous abortion (RSAs) and autoimmune diseases were found to have anti-lipid antibodies and some other antibodies, which negatively regulate phospholipids. However, the relationship between these antibodies and RSAs is unclear.