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探讨血清中食物特异性抗体IgG(sIgG)与溃疡性结肠炎的关系。用ELISA法检测30例溃疡性结肠炎(UC)患者及76名正常对照sIgG,UC患者同时测ANA、C IC、补体C3、C4、CH50、抗脱氧核糖核酸B抗体(抗B抗体),sIgE及皮肤点刺试验。30例UC患者中sIgG阳性者口服5-氨基水杨酸并忌食相关食物,随访6个月观察疗效,与同期就诊的未测sIgG的39例UC患者相比较。30例UC患者中sIgG阳性21例阳性率70.0%,76名健康人中10例阳性,阳性率13.2%.两组相比较有显著性性差异(P<0.01)。治疗组21例,经随访2月总有效率46.7%,6月总有效率66.7%。对照组39名,2月总有效率9.5%,6月总有效率23.8%,两者相比有显著性差异(P<0.01)。食物sIgG检测在UC患者中是有意义的,食物sIgG升高与UC发病有关。
To investigate the relationship between serum specific antibody IgG (sIgG) and ulcerative colitis. Thirty patients with ulcerative colitis (UC) and 76 normal control sIgG were detected by ELISA. The levels of ANA, ICC, complement C3, C4, CH50, anti-deoxyribonucleic acid B (anti-B), sIgE And skin prick test. Among 30 patients with UC, sIgG-positive patients were orally administered 5-aminosalicylic acid without food-related foods. The follow-up of 6 months was used to evaluate the efficacy of sIgG compared with 39 UC patients without sIgG during the same period. Among 30 UC patients, the positive rate of sIgG was 70.0% in 21 cases and 10 of 76 healthy people, the positive rate was 13.2%. There was significant difference between the two groups (P <0.01). 21 cases in the treatment group were followed up for a total effective rate of 46.7% in February, and the total effective rate in June was 66.7%. The control group of 39, the total effective rate of 9.5% in February, the total effective rate of 23.8% in June, there was significant difference between the two (P <0.01). Food sIgG test is meaningful in patients with UC, food increased sIgG and UC pathogenesis.