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目的:通过炎症反应标志物C反应蛋白(CRP)探讨炎症与急性冠状动脉综合征(ACS)、稳定型心绞痛(SAP)的关系,及其在急性心肌梗死(AMI)中发生心脏事件的特点。方法:受试者共 141 例,ACS组 71 例,其中AMI组31例,不稳定型心绞痛(UAP)组40例;SAP组32例;对照组38例。CRP含量测定采用免疫比浊法。结果:①ACS组CRP显著高于对照组。②AMI组 CRP显著高于 UAP组、SAP组、对照组。③UAP组与 SAP组及对照组相比CRP增高,均差异有统计学意义。④SAP组与对照组相比 ,CRP升高差异无统计学意义。⑤AMI组中CRP在发病后48 h达到峰值。⑥AMI组中发生心脏事件亚组的 CRP明显高于其中未发生心脏事件亚组。结论:发生ACS时CRP显著升高,表明ACS过程中存在炎症反应,并在一定程度上反映心肌损伤及坏死的严重程度。AMI中 CRP显著升高时,可较好地预测AMI心脏事件的发生。
Objective: To investigate the relationship between inflammation and acute coronary syndrome (ACS) and stable angina pectoris (SAP) and the occurrence of cardiac events in acute myocardial infarction (AMI) by C reactive protein (CRP), an inflammatory response marker. METHODS: A total of 141 subjects were enrolled in this study. There were 71 ACS patients, including 31 AMI patients, 40 patients with unstable angina pectoris (UAP), 32 SAP patients and 38 control patients. CRP assay using immunoturbidimetry. Results: ① ACS group CRP was significantly higher than the control group. ② CRI in AMI group was significantly higher than that in UAP group, SAP group and control group. ③UAP group compared with SAP group and control group CRP increased, the difference was statistically significant. ④ SAP group compared with the control group, CRP increased no significant difference. ⑤ AMI group CRP peaked at 48 h after onset. ⑥ CRI in subgroup of cardiac events in AMI group was significantly higher than in subgroup of cardiac events in which no cardiac events occurred. CONCLUSIONS: CRP is significantly increased in the presence of ACS, indicating that there is an inflammatory response in ACS and to a certain extent, the severity of myocardial injury and necrosis. AMI CRP was significantly increased, the better predict the occurrence of AMI cardiac events.