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目的:观察不同剂量托吡酯对癫癎大鼠临床发作及脑电活动的影响。方法:选取雄性健康Wistar大鼠60只制作杏仁核点燃模型,然后用托吡酯(分20、40、80 mg／kg三组)进行灌胃,记录用药后杏仁核后放电阈值、皮层及杏仁核后放电持续时间及大鼠双前肢抽动时间。结果:托吡酯灌胃后相同强度电刺激点燃大鼠所需刺激次数明显增加;托吡酯(40、80 mg／kg)灌胃后4 h,杏仁核后放电阈值升高、杏仁核及皮层后放电时程缩短、双前肢抽动时间缩短。结论:托吡酯可明显缩短杏仁核点燃大鼠癫 癎发作时间,缩短杏仁核及皮层后放电持续时间,升高杏仁核后放电阈值。
Objective: To observe the effect of different doses of topiramate on epilepsy rats clinical attack and electroencephalogram. Methods: A total of 60 healthy Wistar rats were selected to make the amygdala litter model. Then the rats were anesthetized with topiramate (20, 40, and 80 mg / kg), and the threshold of amygdala after discharge was recorded. The cortical and amygdala Discharge duration and rat double forelimb twitch time. Results: After the administration of topiramate, the number of stimulation required to fire the rats with the same intensity of electrical stimulation increased obviously. At 4 h after intragastric administration of topiramate (40 and 80 mg / kg), the threshold of amygdala after discharge increased, while the amygdala and cortical after discharge Shorten the process, shortening the time of double forelimb twitching. Conclusion: Topiramate can shorten the time of amygdala lighting the epileptic seizure, shorten the duration of amygdala and cortical discharge, and increase the threshold of amygdala after discharge.