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目的 对照比较药物致肝损害初期及时诊治与肝损害自然演变过程中实施诊治对病情和预后的影响。方法 回顾性分析 6 1例急性药物性肝病的致损伤药物、临床类型及诊治时机对预后的影响。结果 组 1(动态监控组 )与组 2 (对照组 )治愈率 (χ2 =7 0 4 ,P <0 0 1) ,好转率 (χ2 =4 18,P <0 0 5) ,住院时间 (χ2 =5 53,P <0 0 5)比较 ,差异均有显著性。提示组 1较组 2住院时间短、恢复快、预后好。结论 使用可致肝损害的药物期间 ,动态检测肝功能 ,注意发现药物性肝病的肝外表现 ,及早发现亚临床肝损害 ,及时停药及处理 ,有助于改善急性药物性肝病患者的预后。
Objective To compare the effects of medical treatment on the condition and prognosis during the initial diagnosis and treatment of liver damage and the natural evolution of liver damage caused by drugs. Methods A retrospective analysis of 61 cases of acute drug-induced liver disease caused by injury drugs, clinical types and timing of diagnosis and treatment of prognosis. Results The cure rate (χ2 = 704, P <0.01), the improvement rate (χ2 = 4 18, P 0 05), hospitalization time (χ2 = = 533, P <0 05), the differences were significant. Prompt group 1 group 2 shorter hospital stay, faster recovery, good prognosis. Conclusions The use of drugs that can cause liver damage during dynamic detection of liver function, attention to the discovery of extrahepatic manifestations of drug-induced liver disease, early detection of subclinical liver damage, timely withdrawal and treatment will help to improve the prognosis of patients with acute drug-induced liver disease.