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目的分析急性加重期慢阻肺治疗中应用糖皮质激素的效果及对患者动脉血气指标的影响。方法选取我院2011年1月至2013年12月间收治的急性加重期慢阻肺患者84例,随机分为对照组和观察组,对照组给予特布他林,观察组在对照组基础上给予丙酸氟替卡松气雾剂,比较两组治疗效果。结果观察组治疗总有效率95.24%,明显高于对照组的73.81%;治疗后患者FEV1/FVC、FEV1预计值、PEF改善程度均明显优于对照组;PaO2、PaCO2指标结果优于对照组(P均<0.05)。结论急性加重期慢阻肺治疗中加用糖皮质激素可有效改善患者肺功能及动脉血气指标,提高治疗效果,值得临床推广应用。
Objective To analyze the effect of glucocorticoid and its effect on arterial blood gas in COPD patients during acute exacerbation. Methods Eighty-four patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) admitted from January 2011 to December 2013 in our hospital were randomly divided into control group and observation group. The control group was given terbutaline. The observation group was on the basis of the control group Fluticasone propionate aerosol was given to compare the therapeutic effect of the two groups. Results The total effective rate of observation group was 95.24%, which was significantly higher than that of control group (73.81%). After treatment, FEV1 / FVC, FEV1 predictive value and PEF improvement were significantly better than those of control group. PaO2 and PaCO2 indexes were better than those of control group P <0.05). Conclusions Acute exacerbation of chronic obstructive pulmonary disease with glucocorticoid treatment can effectively improve pulmonary function and arterial blood gas index, improve the therapeutic effect, it is worthy of clinical application.