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目的 :了解武汉地区不同献血员血清TTV感染特点及其与其它几种肝炎相关病毒感染之间的关系。方法 :采用PCR及巢式PCR对 54例武汉市城区义务献血员及 74例既往乡村献血者分别进行血清TTVDNA、HCVRNA及HGVRNA等检测。结果 :TTVDNA、HCVRNA及HGVRNA指标阳性率在既往乡村个体献血员为 4 3 .2 %、2 3 .0 %与 2 .7% ,城区义务献血员为 5.6%、1 .9%与 1 .9% ,前者TTVDNA与HCVRNA检出率较后者显著升高 (P <0 .0 1 ) ,两组TTVDNA的检出率显著高于其他肝炎相关病毒。结论 :武汉地区献血员人群存在TTV感染 ,长期的既往献血过程可使职业献血员TTV与HCV感染率升高 ;由此造成的TTV在部分乡村特殊人群中的流行已经成为武汉地区一个值得关注的流行病学问题。
Objective: To understand the characteristics of serum TTV infection among different blood donors in Wuhan and its relationship with several other hepatitis related virus infections. Methods: Serum TTVDNA, HCV RNA and HGVRNA were detected in 54 cases of volunteer blood donors in Wuhan city and 74 cases of past rural donors by PCR and nested PCR. Results: The positive rates of TTVDNA, HCVRNA and HGVRNA were 43.2%, 23.0% and 2.7% respectively in the previous village and 5.6%, 1.9% and 1.9% of the urban volunteer blood donors %, The former detection rate of TTVDNA and HCVRNA was significantly higher than the latter (P <0.01), the detection rate of TTVDNA in both groups was significantly higher than other hepatitis-related viruses. CONCLUSIONS: TTV infection exists in blood donors in Wuhan. The long-term past blood donation process may lead to an increase in the prevalence of TTV and HCV among professional blood donors. The resulting popularity of TTV in some rural special populations has become a concern in Wuhan Epidemiological issues.