【据《Proc Natl Acad Sci U S A》2015年5月报道】题:阻断细胞内凋亡抑制剂可以清除HBV(作者Ebert G等)来自墨尔本大学的Ebert G等已经发现细胞内凋亡蛋白抑制剂(c IAPs)可以通过阻止肿瘤坏死因子(TNF)介导的对感染细胞的杀伤/死亡作用,削弱HBV的清除。对于治疗的重大意义是,这一发现能够转化为治疗药物从而清除感染的细胞。c IAPs抑制剂作为抗癌药物来促进TNF介导的肿瘤杀伤作用。这些药物叫做Smac的模拟物,因为它们可以模拟内源性蛋白Smac/Diablo的作用来拮抗c IAP的功能。通过具有免疫能力的慢性HBV感染小鼠发现,birinapant和其他的Smac模拟物可以快速的降低血清HBV DNA和HBc Ag,并且他们可以 According to “Proc Natl Acad Sci USA” May 2015 Report Title: Blocking of Intracellular Inhibitors of Apoptosis to Clear HBV (by Ebert G, et al.) Ebert G et al from the University of Melbourne have found that intracellular inhibitors of apoptosis proteins (c IAPs) can impair the clearance of HBV by blocking tumor necrosis factor (TNF) -mediated killing / killing of infected cells. The great significance for treatment is that this finding can be translated into therapeutic drugs to clear infected cells. c IAPs inhibitors as anti-cancer drugs to promote TNF-mediated tumor killing. These drugs are called Smac mimics because they mimic the action of the endogenous protein Smac / Diablo to antagonize c IAP function. Infection of mice with immunocompetent chronic HBV found that birinapant and other Smac mimics rapidly lowered serum HBV DNA and HBc Ag, and that they could