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目的了解广西地区艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人(简称HIV/AIDS病人)经高效联合抗反转录病毒治疗(HAART)超过6个月后,所患疾病谱及对预后的影响。方法回顾性分析2010年4月至2015年3月HAART超过6个月后,HIV/AIDS病人住院的主要原因。将所患疾病分类为:HAART药物不良反应、急性感染性疾病、传染性肝病、结核病、其他传染病、内科系统疾病、外科系统疾病、外伤、肿瘤、其他疾病,共10类。观察各类疾病的发生情况及对预后的影响。结果共收集符合条件的病人818例,男性占71.1%,年龄>50岁的占47.1%,CD4+T淋巴细胞计数<200个/μL者占32.5%。各类疾病中,急性感染性疾病占19.6%,内科系统性疾病占17.0%,外科系统性疾病占13.8%,肿瘤占12.6%,HAART药物不良反应占8.3%,结核病占8.9%,传染性肝病占5.7%,其他传染病占5.0%,外伤占3.7%,其他疾病占5.4%。不良预后病人占10.9%。其中前三位为恶性肿瘤(47.2%)、急性感染(25.8%)和慢性肝病(9.0%)。结论广西地区HIV/AIDS病人基础免疫低下多见,中长期HAART过程中感染性疾病风险较大,老年人比例高,合并病种多样,恶性肿瘤和感染是不良预后的主要原因。
Objective To understand the prevalence of disease and prognosis in HIV / AIDS patients (HIV / AIDS patients) in Guangxi after more than 6 months of HAART combined with antiretroviral therapy (HAART) influences. Methods Retrospective analysis of the main reasons for hospitalization of HIV / AIDS patients after HAART from April 2010 to March 2015 was more than 6 months. The disease is classified as: HAART adverse drug reactions, acute infectious diseases, infectious liver disease, tuberculosis, other infectious diseases, medical system diseases, surgical system diseases, trauma, cancer, other diseases, a total of 10 categories. Observe the occurrence of various diseases and prognosis. Results A total of 818 eligible patients were collected, accounting for 71.1% of men, 47.1% of whom were over 50 years of age and 32.5% of those with CD4 + T lymphocyte counts <200 / μL. Among the various diseases, 19.6% were acute infectious diseases, 17.0% were systemic medical diseases, 13.8% were surgical systemic diseases, 12.6% were oncological tumors, 8.3% were HAART drug adverse reactions, 8.9% were tuberculosis, and infectious liver disease Accounting for 5.7%, other infectious diseases accounted for 5.0%, trauma 3.7%, other diseases accounted for 5.4%. Poor prognosis patients accounted for 10.9%. The top three were malignant (47.2%), acute (25.8%) and chronic (9.0%). Conclusions The basic immunocompromise of HIV / AIDS patients in Guangxi is more common. The risk of infectious diseases in the middle-long term HAART is higher, the proportion of the elderly is high, the patients with multiple diseases are merged, and the malignant tumor and infection are the main reasons of poor prognosis.