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神经肽Y（NPY）是广泛分布于中枢神经系统和外周神经各部位的神经肽类物质。本实验观察NPY在体外对几种免疫细胞活性的直接作用。结果表明，NPY对小鼠T淋巴细胞丝裂原反应性和NK细胞的杀伤活性均无明显影响（P＞0．05），对巨噬细胞分泌溶菌酶有明显抑制作用（P＜0．05）；而对B淋巴细胞丝裂原反应性则有明显的促进作用（P＜0．05）。上述结果提示，NPY对部分免疫细胞功能的影响因细胞种类而异。
Neuropeptide Y (NPY) is a neuropeptide substance widely distributed in various parts of the central nervous system and peripheral nerves. This experiment observed the direct effect of NPY on several immune cell activities in vitro. The results showed that NPY had no significant effect on the mitogenic reactivity of T lymphocytes and the killing activity of NK cells (P> 0.05), but significantly inhibited the secretion of lysozyme by macrophages (P <0.05 ), While the mitogenic reactivity of B lymphocytes was significantly enhanced (P <0.05). The above results suggest that the effects of NPY on the function of some immune cells vary with cell types.