染色体易位在肿瘤中很常见,但其发生的分子机制复杂,目前尚未完全阐明。近年的研究显示,细胞核基因组的组织结构是高度有序的,每条染色体或染色质都有自己的位置和领地,它们相互交错,共同维持着基因转录网。肿瘤细胞染色体易位的非随机性被认为与间期核内染色体或基因的空间位置密切相关。染色体易位通常发生在核内邻近的染色体或空间位置接近的基因。这些发现对肿瘤的早期诊断和靶向治疗具有重要意义。 Chromosomal translocations are common in tumors, but their molecular mechanisms are complex and are not yet fully elucidated. Recent studies have shown that the organization of the nuclear genome is highly ordered. Each chromosome or chromatin has its own location and territory, which are intertwined to maintain the gene transcription network. The nonrandomity of tumor cell chromosomal translocations is thought to be closely related to the spatial location of interphase chromosomes or genes. Chromosomal translocations usually occur in adjacent chromosomes in the nucleus or close to the gene in space. These findings are of great importance for early diagnosis and targeted therapy of tumors.