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目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者血清降钙素原(PCT)浓度变化及其临床意义,为临床治疗提供科学依据。方法选择台州市黄岩区中医院呼吸科自2011年12月至2013年12月住院的患者54例为病例组,同期住院的患者54例为对照组。对两组白细胞(WBC)、C-反应蛋白(CRP)、PCT进行检测,并对AECOPD患者不同PCT浓度与痰培养和病情进行相关性分析。结果对照组WBC、CRP、PCT分别为(8.18±4.73)×109/L、(19.63±13.26)mg/L和(3.42±1.38)μg/L,病例组分别为(13.43±6.29)×109/L、(68.24±14.57)mg/L和(8.35±2.46)μg/L,两组比较,差异均有统计学意义(P<0.01);不同PCT浓度组痰培养和病情比较,差异均有统计学意义(χ2值分别为16.20、14.04,P<0.01);不同PCT浓度组WBC计数和CRP比较,差异均有统计学意义(F值分别为66.45、12.47,P<0.01)。病例组PCT浓度与AECOPD病情呈显著正相关(r=0.761,P<0.01)。结论血清PCT浓度能反映AECOPD患者细菌感染程度,具有重要的临床意义。
Objective To investigate the changes of serum procalcitonin (PCT) concentration and its clinical significance in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and to provide a scientific basis for clinical treatment. Methods Sixty-four cases of patients hospitalized in Department of Respiratory Medicine, Huangyan District Chinese Medicine Hospital of Taizhou from December 2011 to December 2013 were selected as the case group and 54 cases of hospitalized patients as control group. Two groups of white blood cells (WBC), C-reactive protein (CRP), PCT were detected, and AECOPD patients with different concentrations of PCT and sputum culture and disease were analyzed. Results The WBC, CRP and PCT were (8.18 ± 4.73) × 109 / L, (19.63 ± 13.26) mg / L and (3.42 ± 1.38) μg / L respectively in the control group and (13.43 ± 6.29) × 109 / L, (68.24 ± 14.57) mg / L and (8.35 ± 2.46) μg / L, respectively, with significant difference between the two groups (P <0.01). There was statistical difference in sputum culture and disease condition between different PCT concentration groups (Χ2 = 16.20,14.04, P <0.01). There were significant differences in WBC count and CRP between different PCT concentrations (F = 66.45,12.47, P <0.01). There was a significant positive correlation between PCT concentration and AECOPD in case group (r = 0.761, P <0.01). Conclusion Serum PCT concentration can reflect the degree of bacterial infection in patients with AECOPD, has important clinical significance.