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评价肌注免疫球蛋白（ＩＭＩＧ）和绒毛膜促性腺激素（ｈＣＧ）治疗反复自然流产（ＲＳＡ）的效果。方法通过对反复自然流产患者４１２例的常规检查，筛查出不明原因反复自然流产１９８例（４８．１％），对再次妊娠的１６３例进行治疗，其中治疗组１０３例，给予ＩＭＩＧ和ｈＣＧ治疗；ｈＣＧ对照组３０例，单纯给予ｈＣＧ治疗；黄体酮对照组３０例，单纯给予黄体酮治疗。结果ＩＭＩＧ和ｈＣＧ治疗组已分娩９６例，妊娠近足月２例，妊娠成功率为９５．１％（９８／１０３）；ｈＣＧ对照组已分娩１８例，妊娠成功率６０．０％（１８／３０）；黄酮体对照组，已分娩１１例，妊娠成功率为３７．３％（１１／３３）。ｈＣＧ、黄体酮对照组妊娠成功率分别与ＩＭＩＧ和ｈＣＧ治疗组比较，差异有显著性（χ２＞４９，Ｐ＜０．０１）。结论ＩＭＩＧ和ｈＣＧ联合应用治疗ＲＳＡ是安全、有效的。
To evaluate the effect of intramuscular immunoglobulin (IMIG) and chorionic gonadotropin (hCG) on recurrent spontaneous abortion (RSA). Methods Through routine examination of 412 cases of recurrent spontaneous abortion, 198 cases (48.1%) of unexplained recurrent spontaneous abortion were screened and 163 cases were treated again. Among them, 103 cases were treated with IMIG and hCG ; 30 cases of hCG control group were treated with hCG alone; 30 cases of progesterone control group were treated with progesterone alone. Results In the IMIG group and the hCG group, 96 cases had been delivered and 2 cases had nearly full-term pregnancy. The pregnancy success rate was 95.1% (98/103). In the hCG control group, 18 cases were delivered and the pregnancy success rate was 60.0% (18 / 30). Flavonoids control group had 11 cases of childbirth, pregnancy success rate was 37.3% (11/33). The pregnancy success rates of hCG and progesterone control group were significantly different from that of IMIG and hCG treatment group (χ2> 49, P <0.01). Conclusion The combination of IMIG and hCG in the treatment of RSA is safe and effective.