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胆汁酸(BA)是胆汁中的主要成分,在发生十二指肠胃返流(DGR)时BA随十二指肠液逆流入胃,引起胃粘膜损伤,有人认为BA与胃癌的发生亦有关。以往有关BA与胃炎、胃癌关系的临床研究多限于手术后残胃。为了探讨BA在非手术胃慢性胃炎发病中的地位,本文测定了102例慢性胃炎患者基础一小时胃液胆汁酸、亚硝酸盐含量和基础血清胃泌素水平,并观察了注射五肽胃泌素对DGR的影响,现将结果报道如下。
Bile acid (BA) is the main component in bile. When duodenal reflux (DGR) occurs, BA flows back into the stomach with duodenal fluid, causing gastric mucosal damage. Some people think that BA is also related to the occurrence of gastric cancer. In the past, clinical studies on the relationship between BA and gastritis and gastric cancer were mostly limited to residual stomach after surgery. In order to investigate the role of BA in the pathogenesis of non-surgical gastric chronic gastritis, 102 patients with chronic gastritis were measured for bile acid, nitrite content, and basal serum gastrin levels during the first hour, and observations were made for the administration of pentagastrin. The impact of DGR is now reported as follows.