论文部分内容阅读
脑膜炎奈瑟菌表面蛋白H因子结合蛋白(f HBP),是脑膜炎奈瑟菌的外膜蛋白和重要毒力因子,能与补体调节蛋白H因子结合。结合于脑膜炎奈瑟菌表面的H因子,能下调补体系统的激活作用,使脑膜炎奈瑟菌逃避补体系统的攻击。f HBP能诱导机体产生高水平的保护性抗体,抗f HBP抗体与f HBP结合后可阻止f HBP与H因子的结合,从而使细菌易于被补体系统杀灭和清除。因此,f HBP已成为B群流行性脑脊髓膜炎理想的疫苗候选抗原之一。现就f HBP的结构、基因的表达与调节、作为B群脑膜炎奈瑟菌疫苗候选抗原的作用、应用策略、安全性和有效性等最新研究进展进行综述。
Neisseria meningitidis surface protein H factor-binding protein (f HBP), an outer membrane protein of N. meningitidis and an important virulence factor, binds to complement factor H factor. The H factor, which binds to the surface of N. meningitidis, can down-regulate the activation of the complement system, allowing Neisseria meningitidis to evade the complement system attack. f HBP can induce the body to produce a high level of protective antibodies, and the combination of f HBP and f HBP can prevent the binding of f HBP and factor H so that bacteria can be easily killed and eliminated by the complement system. Therefore, f HBP has become one of the ideal vaccine candidate antigens for group B meningococcal meningitis. The recent progress in research on the structure and gene expression and regulation of f HBP, as a candidate antigens of Neisseria meningitidis group B vaccine, application strategies, safety and efficacy are summarized.